Physician and patient interest in growth hormone replacement therapy for adults is increasing. To provide a general and brief overview of the key issues related to human growth hormone, we arrived at group consensus on the topics that needed to be addressed, at least broadly, on growth hormone therapy for adults. We identified and cited key references for each topic, as well as included clinical applications based on one author’s experience treating patients. We highlighted a few studies showing particular promise for growth hormone therapy. Studies, new and old, provide convincing evidence that growth hormone enhances health and quality of life. When acquired from a reliable, safe, approved pharmaceutical supplier and administered under proper clinical guidelines and at proper physiological dosages by a qualified physician, growth hormone may be a clinically safe and effective component of a broader preventative and maintenance therapy approach to a patient’s health. Skepticism, however, remains over the benefits of growth hormone treatment. This article does not represent an exhaustive review of the literature; rather, it offers an environmental scan of hormone replacement therapy issues.